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Prof C Selman
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
Start date: 1st Oct 2013
Stipend: £13,726 per annum
Ageing is defined as the decline in survival and fecundity with advancing age. It is associated with progressive physiological deterioration, functional impairment and an increased risk of pathologies including dementia and various cancers. In developed countries, average life expectancy has increased by over 30 years since 1900, with this ‘greying’ of the population likely to present significant medical, societal and economic challenges to future generations. Consequently, the identification of the cellular mechanisms that underlie cause ageing is a fundamental research question in science today. While we know that the ageing process can be modulated through both genetic and environmental interventions in model organisms, we still do not know how these beneficial effects come about. One such intervention is dietary restriction (DR), where an individual eats ~30-40% less food each day, which can increase both lifespan and delay many age-related diseases. However, it has recently been shown that the effects of DR are not universal, as previously thought.
In this project we will study ILSXISS recombinant inbred mice (Liao et al. 2010; Rikke et al 2010) which show marked genetic variation in lifespan in response to DR. This flexible project will employ a range of molecular, cellular and physiological techniques in order to gain novel insights into how DR acts to extend healthy lifespan in mammals. The diverse training, infrastructure and stimulating environment will enable a talented individual to develop a wide range of skills and a critical understanding of biogerontology.
Prospective candidates are encouraged to contact Prof. Selman [Email Address Removed] in the first instance.
Applicants should have a minimum of an upper second-class degree or its equivalent, in a biomedical or related subject.
Stipend: £13,726 per annum
Ageing is defined as the decline in survival and fecundity with advancing age. It is associated with progressive physiological deterioration, functional impairment and an increased risk of pathologies including dementia and various cancers. In developed countries, average life expectancy has increased by over 30 years since 1900, with this ‘greying’ of the population likely to present significant medical, societal and economic challenges to future generations. Consequently, the identification of the cellular mechanisms that underlie cause ageing is a fundamental research question in science today. While we know that the ageing process can be modulated through both genetic and environmental interventions in model organisms, we still do not know how these beneficial effects come about. One such intervention is dietary restriction (DR), where an individual eats ~30-40% less food each day, which can increase both lifespan and delay many age-related diseases. However, it has recently been shown that the effects of DR are not universal, as previously thought.
In this project we will study ILSXISS recombinant inbred mice (Liao et al. 2010; Rikke et al 2010) which show marked genetic variation in lifespan in response to DR. This flexible project will employ a range of molecular, cellular and physiological techniques in order to gain novel insights into how DR acts to extend healthy lifespan in mammals. The diverse training, infrastructure and stimulating environment will enable a talented individual to develop a wide range of skills and a critical understanding of biogerontology.
Prospective candidates are encouraged to contact Prof. Selman [Email Address Removed] in the first instance.
Applicants should have a minimum of an upper second-class degree or its equivalent, in a biomedical or related subject.
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