Investigation of novel nanoparticles for theranostic applications

In collaboration with the Profs. Gary Green (Neuroimaging Centre, University of York), Roy Chantrell (Condensed Matter Theory, University of York) and Chris Binns (University of Leicester) this PhD project aims to develop novel approaches for nanoparticles with specific microstructural and magnetic properties to be used for biomedical applications. Magnetic nanoparticles have been shown to be applicable for increased contrast in magnetic resonance imaging (MRI) as well as for disease therapy using time dependent magnetic fields to transfer thermal energy to specific sites within the human body (called hyperthermia). The combination of both (diagnostics + therapy = theranostics) employing the same nanoparticles giving both high magnetic response for hyperthermia and long spin relaxation times for MRI is an area of research with a great degree of novelty. The planned work will target the analysis of the microstructure of cluster deposited metal/semiconductor and core-shell nanoparticles as well as their magnetic properties in close cooperation feeding into ongoing research on applicability and theoretical understanding of atomic structure and magnetic properties.

The PhD project will provide a broad set of skills to the student regarding micro- and mesoscale characterization of nanoparticles and nanoparticle/organic interfaces using state-of-the-art electron microscopy and Raman microscopy. It also provides a substantial exposure of the student to interdisciplinary experience crossing the boundaries between Physics and Life Science as well as Experiment and Theory. The collaborations with the project partners will also allow to obtain intensive insight into experimental and theoretical techniques usually not available to experimental physics students (such as MRI and molecular dynamic modeling) giving him or her vital advantages on the job market.