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Dr Andrew Mendham
No more applications being accepted
Funded PhD Project (Students Worldwide)
About the Project
Research into naturally occurring and synthetic diketopiperazine (DKP) derivatives is an exciting area of significant contemporary scientific interest.
The objective of this project is to synthesise a range of novel DKP derivatives for potential clinical activities. Various instrumental techniques will be utilised in order to determine the purity, structure and conformation of DKP derivatives in the solid, solution and gaseous states; namely NMR (solid and solution state), MS, dispersive Raman/surface enhanced Raman, infra-red spectroscopy, temperature dependent XRPD and single crystal X-ray diffraction.
Gaussian and CASTEP molecular modelling packages will be used to determine the theoretical structures of the synthesised molecules in the solid, solution and gaseous phases. In addition, the modelling packages will be utilised to obtain theoretical spectroscopic data in order to compare and contrast with experimental data outputs.
Applications are sought by the indicated closing date for starting in November 2013.
The objective of this project is to synthesise a range of novel DKP derivatives for potential clinical activities. Various instrumental techniques will be utilised in order to determine the purity, structure and conformation of DKP derivatives in the solid, solution and gaseous states; namely NMR (solid and solution state), MS, dispersive Raman/surface enhanced Raman, infra-red spectroscopy, temperature dependent XRPD and single crystal X-ray diffraction.
Gaussian and CASTEP molecular modelling packages will be used to determine the theoretical structures of the synthesised molecules in the solid, solution and gaseous phases. In addition, the modelling packages will be utilised to obtain theoretical spectroscopic data in order to compare and contrast with experimental data outputs.
Applications are sought by the indicated closing date for starting in November 2013.
Funding Notes
Bursary available (subject to satisfactory performance):
Year 1: £13726 Year 2: In line with RCUK rate Year 3: In line with RCUK rate
Home and EU - In addition, the successful candidate will receive a contribution to tuition fees equivalent to the university’s Home/EU rate for the duration of their scholarship.
International students will have to pay the difference between International and Home/EU tuition fees.
International students, please look at the following link for English Language requirements:
http://www2.gre.ac.uk/research/study/studentships
Year 1: £13726 Year 2: In line with RCUK rate Year 3: In line with RCUK rate
Home and EU - In addition, the successful candidate will receive a contribution to tuition fees equivalent to the university’s Home/EU rate for the duration of their scholarship.
International students will have to pay the difference between International and Home/EU tuition fees.
International students, please look at the following link for English Language requirements:
http://www2.gre.ac.uk/research/study/studentships
References
Title: Vibrational spectroscopy and crystal structure analysis of two polymorphs of the di-amino acid peptide cyclo(L-Glu-L-Glu)
Author(s): Mendham, Andrew P.; Palmer, Rex A.; Potter, Brian S.; et al.
Source: JOURNAL OF RAMAN SPECTROSCOPY Volume: 41 Issue: 3 Pages: 288-302 DOI: 10.1002/jrs.2467 Published: MAR 2010
Title: 2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products Author(s): Borthwick, Alan D.
Source: CHEMICAL REVIEWS Volume: 112 Issue: 7 Pages: 3641-3716 DOI: 10.1021/cr200398y Published: JUL 2012
Author(s): Mendham, Andrew P.; Palmer, Rex A.; Potter, Brian S.; et al.
Source: JOURNAL OF RAMAN SPECTROSCOPY Volume: 41 Issue: 3 Pages: 288-302 DOI: 10.1002/jrs.2467 Published: MAR 2010
Title: 2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products Author(s): Borthwick, Alan D.
Source: CHEMICAL REVIEWS Volume: 112 Issue: 7 Pages: 3641-3716 DOI: 10.1021/cr200398y Published: JUL 2012
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