Investigating the structure and function of active genes in amphibian oocytes at University of Nottingham on FindAPhD.com

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Dr G T Morgan Applications accepted all year round Competition Funded PhD Project (Students Worldwide)

About the Project

We are using the giant nuclei found in amphibian oocytes to explore the relationship between gene expression and nuclear organisation. A combination of factors means that oocytes contain nuclear structures with extraordinary levels of morphological detail, the best known of which are the giant lampbrush chromosomes. These chromosomes are unique in allowing the analysis of transcription sites with a clearly defined structure. This project wil aim to use the approaches of molecular cell biology to investigate the extent to which a more downstream aspect of eukaryotic gene expression, the processing of introns, is coupled to the transcription of particular nascent RNAs.

Applicants should complete the on-line application form at https://
pgapps.nottingham.ac.uk/ and submit two confidential referees’ reports and copies of
transcripts/academic certificates as soon as possible.

Funding Notes

UK and EU Applicants: Full (fees and living stipend of £13,290 pa) is provided in the form of studentships to selected candidates. Selection is based on best candidates applying to School. Although the vast majority of our home students are fully funded we have traditionally attracted a number of students willing to fund their own training.

International Applicants: There are a number of international studentships available, see http://www.nottingham.ac.uk/prospectuses/postgrad/introduction/funding/postscholarship.php
Normally these studentships provide only tuition fees so applicants should be able to provide at least their own living expenses for the duration of the course.

References

Morgan, G.T., In press. Localized co-transcriptional recruitment of the multifunctional RNA-binding protein CELF1 by lampbrush chromosome transcription units. Chromosome Research, 15(8).

Smith, A.J., Ling, Y. and Morgan, G.T. (2003) Subnuclear localization and Cajal body targeting of transcription elongation factor TFIIS in amphibian oocytes. Mol. Biol. Cell 14: 1255-1267.

Morgan, G.T. (2002) Lampbrush chromosomes: new insights into principles of nuclear structure and function. Chromosome Res. 10: 177-200.

Morgan, G.T., Doyle, O., Murphy, C. and Gall, J.G. (2000) RNA polymerase II in Cajal bodies of amphibian oocytes. J. Struct. Biol. 129: 258-268.

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Investigating the structure and function of active genes in amphibian oocytes

University of Nottingham School of Life Sciences