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Faculty of Biology, Medicine and Health

The University of Manchester
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  Enteroendocrine cell fatty acid sensing in health and disease

Prof Craig Smith  Applications accepted all year round  Self-Funded PhD Students Only
Manchester United Kingdom

About the Project

Intestinal nutrient sensing is paramount for optimal digestion of ingested foods and is implicated in the aetiology of major diseases including diabetes and obesity. Key to intestinal nutrient sensing are enteroendocrine cells acting to sense and transduce nutrient signals. Little is known about the mechanisms that mediate nutrient induced signals. This project focuses on ‘I cells’ expressed in the duodenum. These cells represent less than 1% of the total small intestinal mucosa and contain the satiety peptide hormone cholecystokinin. We have developed a method to purify I cells and the aim of this project is to study the physiology of these cells and to determine their role in nutrient sensing in health and disease. This project involves a broad spectrum of techniques including cell physiology, immunocytochemistry and molecular biology.

Funding Notes

To apply for this PhD project please see:
http://www.ls.manchester.ac.uk/phdprogrammes/apply/

Where will I study?

 About the Project

 About the Project  Funding Notes

Faculty of Biology, Medicine and Health

Tackle real world challenges, make a difference, and elevate your career with postgraduate research in the Faculty of Biology, Medicine and Health at Manchester. From biochemistry to neuroscience, cancer sciences to medicine, audiology to mental health and everything in between, we offer a wide range of postgraduate research projects, programmes and funding which will allow you to immerse yourself in an area of research you’re passionate about.

Why study at the Faculty of Biology, Medicine and Health?

Experience PhD life as part of a diverse postgraduate research community of more than 1,000 postgraduate researchers at the 29th most international university in the world (Times Higher Education, 2023).

Ranked the best place to live in the UK (The Economist Global Liveability Index, 2022), Manchester boasts world-class culture, iconic sports, a thriving music and food scene, and much more. It's not just a place to research, it's a place to call home.

With 93% of research activity at the University rated as 'world-leading' or 'internationally excellent' (Research Excellence Framework, 2021), you'll get the chance to have an impact on global health and science challenges.

1000+

postgraduate students

1

PhD

6th

in the UK - QS (2025)

Manchester  United Kingdom

main campus

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About the Faculty of Biology, Medicine and Health

At Manchester, postgraduate researchers are at the heart of our mission to tackle pressing global challenges in biological, medical and healthcare sciences - and you could be too.

By choosing Manchester for your postgraduate research, you’ll be joining a university with an exceptional research reputation, where 93% of research is world-leading or internationally excellent (REF, 2021) and where your work will have real-world impact.

You’ll research in world-class facilities alongside leading experts at the forefront of innovation, collaborating across disciplines to pioneer new treatments, advance scientific knowledge, and improve healthcare globally.

Supported by our dedicated Doctoral Academy and strong industry links, you'll experience PhD life in a vibrant, welcoming and diverse postgraduate research community.

And you’ll leave with the specialist knowledge, research experience and transferable skills that will shape your future in academia, research or industry.

Main campus

The University of Manchester

Manchester

North West

United Kingdom

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Institution profile for The University of Manchester More details

The epigenomic, transcriptional and diagnostic architecture of neurodevelopmental disorders caused by exposure to maternal infection

The University of Manchester Faculty of Biology, Medicine and Health
A fundamental unknown in understanding mechanisms of disease, and therefore improving therapy, is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult disease (Estes & McAllister 2016). Read more
 Supervisors: Dr R Hager, Dr M Harte, Dr J Glazier
 Year round applications  Self-Funded PhD Students Only  PhD Research Project
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