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Prof Stuart Allan
Applications accepted all year round
Self-Funded PhD Students Only
About the Project
Inflammation is now recognised as a key contributor to neuronal injury in both acute and chronic neurodegenerative disease. Many studies in this area have focussed on the post-injury inflammatory response and in particular on the role of specific cytokines in the central nervous system. A key mediator, identified from both experimental and clinical studies, is interleukin-1 and this has been the focus of much of our research for the last few years. However, increasing interest has now been focussed on the peripheral response to injury and also on the inflammatory status before injury. This is particularly true for acute conditions, such as stroke, where preceding infection is a major risk factor. Recent data also indicate that peripheral inflammation has an important role in chronic conditions, such as epilepsy and Alzheimer’s disease.
This project will therefore assess the contribution of peripheral inflammation both before and after injury, using appropriate experimental paradigms.
This project will therefore assess the contribution of peripheral inflammation both before and after injury, using appropriate experimental paradigms.
Funding Notes
References
Denes A, Thornton P, Rothwell NJ & Allan SM (2010) Inflammation and brain injury: Acute cerebral ischaemia, peripheral and central inflammation. Brain Behav. Immun. 24:708-23
Esiri MM (2007) The interplay between inflammation and neurodegeneration in CNS disease. J. Neuroimmunol. 184:4-16
Esiri MM (2007) The interplay between inflammation and neurodegeneration in CNS disease. J. Neuroimmunol. 184:4-16
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