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  Diet, obesity and the brains control of the gastrointestinal system


   Faculty of Biological Sciences

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Dr D I Lewis  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Obesity has become a global pandemic affecting billions of individuals worldwide. The brain is the key to the development of new treatments for this often life-threatening disorder. If we can increase our understanding of how the brain controls the gastrointestinal system and what happens when these control systems malfunction or fail, then we may be able to develop new treatments for obesity or even ways to stop it occurring; either of which would result in substantial health, social and financial benefits for mankind.

We are interested in how the motoneurones within the hindbrain which control the gastrointestinal systems are regulated; both by higher brain regions and by metabolic signals. We are also interested in what happens when things go wrong. What we eat has a major influence in determining whether or not we become obese. However, diet can have a much earlier effect; studies in both humans and animals have shown that what your mother ate whilst pregnant or during breast-feeding can also increase the risk of you becoming obese in later life. Therefore, we are also investigating the influence of maternal diet during pregnancy and weaning on the development of these hindbrain circuits in the offspring.

To address these questions we use a multidisciplinary approach, predominantly using whole animal (in-vivo) experimental techniques and preparations. We combine these with neuroanatomical, electrophysiological and molecular biological techniques as appropriate.

Potential projects include:

Hypothalamic modulation of hindbrain gastrointestinal circuits
Does food composition modulate gastrointestinal reflexes and motor outflows?
Does maternal diet alter the development of hindbrain gastrointestinal circuits?

Other similar projects may also be availiable, please contact me. Futher information see: http://www.fbs.leeds.ac.uk/staff/profile.php?tag=Lewis

Funding Notes

Self funded students are welcome to apply at any time. A limited number of funded studentships are available, see http://www.fbs.leeds.ac.uk/gradschool/index.htm for details and deadlines.

References

Poole SL, Lewis DI, Deuchars SA. (2008) Histamine depolarizes neurons in the dorsal vagal complex. Neurosci Lett. 432(1):19-24.

Lewis DI, Coote JH. (2008). Electrophysiological characteristics of vasomotor preganglionic neurons and related neurons in the thoracic spinal cord of the rat: an intracellular study in vivo. Neuroscience. 152(2):534-46.

Dallas ML, Morris NP, Lewis DI, Deuchars SA, Deuchars J. (2008) Voltage-gated potassium currents within the dorsal vagal nucleus: inhibition by BDS toxin. Brain Res. 1189:51-7.

Poole SL, Deuchars J, Lewis DI, Deuchars SA. (2007) Subdivision-specific responses of neurons in the nucleus of the tractus solitarius to activation of mu-opioid receptors in the rat. J Neurophysiol. 98(5):3060-71.

Dallas ML, Atkinson L, Milligan CJ, Morris NP, Lewis DI, Deuchars SA, Deuchars J. (2005) Localization and function of the Kv3.1b subunit in the rat medulla oblongata: focus on the nucleus tractus solitarii. J Physiol. 562(Pt 3):655-72.

Bouryi VA, Lewis DI. (2004) Enkephalinergic inhibition of raphe pallidus inputs to rat hypoglossal motoneurones in vitro. Neuroscience. 129(1):55-64.

Bouryi VA, Lewis DI. (2003) The modulation by 5-HT of glutamatergic inputs from the raphe pallidus to rat hypoglossal motoneurones, in vitro. J Physiol. 553(Pt 3):1019-31.


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Project supervisors

Career overview

Prof. Dave Lewis is currently the Professor of Education for Professional and Sustainable Development in the School of Biomedical Sciences at the University of Leeds, a position he has held since 2024. He joined the School in 1999 as a Lecturer, was appointed Senior Lecturer in 2004, and has since made significant contributions to the field of education. Prof. Lewis has also held a secondment with the Interdisciplinary Ethics Applied Centre and has been a Fellow with the Leeds Institute of Teaching Excellence. He serves as the Academic Lead for Capstone projects within the University’s Curriculum Redefined programme, which aims to transform educational practices. Before his tenure at Leeds, Prof. Lewis was a PhD student and subsequently a Postdoctoral Research Associate (PDRA), independent Senior Research Fellow, and Lecturer in the Department of Physiology at the University of Birmingham. His PhD studies, supervised by Professor John H Cooote, focused on animal models to investigate the neurophysiology and pharmacology of the brain''s pathways controlling the cardiorespiratory systems. Prof. Lewis has held visiting professorships at the University of Lincoln and the University of Ulster, and has been an External Lecturer at various institutions, including the Karolinska Institutet in Sweden and universities in South Africa and Algeria. He has received numerous prestigious awards for his contributions to education, including the Biochemical Society’s Teaching Excellence Award in 2022 and the British Pharmacological Society’s Zaimis Prize for Sustained Achievement and Leadership in Pharmacology Education in 2021. In addition to his academic roles, Prof. Lewis is the Deputy Vice-President (Academic Development) of the British Pharmacological Society and chairs the International Union of Basic and Clinical Pharmacology’s Integrative and Organ Systems Pharmacology Initiative. He is also a co-founder of the Pan-African Network for Laboratory Animal Science and Ethics and a member of the Stakeholder Board of the EU Education and Training Platform for Laboratory Animal Science.


Research interests

Prof. Lewis''s research focuses on education for professional and sustainable development, particularly through experiential learning and capstone projects. He aims to enhance graduate outcomes by developing research-based educational opportunities that prepare students for diverse careers beyond traditional research paths. Prof. Lewis has created a portfolio of capstone enquiry-based projects that address employer demands for work-ready experiences and competencies. His work also includes creating collaborative online education for sustainable development, fostering partnerships between institutions in the Global South and North. This initiative allows students to learn from each other''s cultural experiences while co-creating solutions to UN Sustainable Development Goals. In the area of research animal sciences, welfare, and ethics, Prof. Lewis collaborates internationally to provide professional education courses related to the care and use of animals in research. He co-founded the Pan-African Network for Laboratory Animal Science and Ethics (PAN-LASE), which has educated numerous stakeholders across Africa and developed guidelines and frameworks for ethical review committees. Prof. Lewis is passionate about research ethics and has contributed significantly to the development of research ethics policies at the University of Leeds. He leads initiatives to strengthen ethical review processes in the Global South and has created the 12Rs Framework to help researchers navigate ethical issues in animal research. His educational research activities aim to support learners in their transition to professional careers and lifelong learning.

View Prof. Dave Lewis's profile