Structure and function of enzymes involved in glycolipid biosynthesis: targets for structure-based drug design

Glycolipid biosynthesis is a critical aspect of metabolism and essential for many serious pathogens. Several key enzymes have been identified and will be the focus of this project. The genes will be cloned, protein expression systems constructed, samples purified and crystallized for subsequent structural and functional analysis. The project will extend to the study of enzyme-ligand interactions, which will include use of a range of biophysical and computational methods. These analyses will underpin efforts to derive novel lead compounds for therapeutic use.

Projects are designed to suit the background and interests of the student. Applicants with degrees in biochemistry, molecular biology, chemistry or physics are invited to apply. Training will be given in the bioinformatics planning, protein chemistry, X-ray techniques and computing methods that can be applied to the project. There is also the possibility of spending some time at the European Synchrotron in Grenoble, France.