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Prof David Leak
Applications accepted all year round
Self-Funded PhD Students Only
About the Project
Project description
Geobacillus spp have been shown to be versatile organisms for the production of ethanol from lignocellulosic wastes (Cripps et al (2009) Metabolic Engineering 398–408), including municipal solid waste. Ethanol is a natural product of energy metabolism and so it is relatively straightforward to make production an obligatory part of growth. Partitioning carbon flux between more general metabolite formation and growth is a more significant challenge but this is now being successfully addressed in model organisms such as E coli ( eg Solomon et al(2012)Metabolic Engineering 661–671). In this project we intend to apply and develop these strategies to achieve flux partition in Geobacillus spp.
Suitable for students with a first degree in Microbiology, Biochemistry or Biochemical Engineering.
Geobacillus spp have been shown to be versatile organisms for the production of ethanol from lignocellulosic wastes (Cripps et al (2009) Metabolic Engineering 398–408), including municipal solid waste. Ethanol is a natural product of energy metabolism and so it is relatively straightforward to make production an obligatory part of growth. Partitioning carbon flux between more general metabolite formation and growth is a more significant challenge but this is now being successfully addressed in model organisms such as E coli ( eg Solomon et al(2012)Metabolic Engineering 661–671). In this project we intend to apply and develop these strategies to achieve flux partition in Geobacillus spp.
Suitable for students with a first degree in Microbiology, Biochemistry or Biochemical Engineering.
Funding Notes
**We welcome year-round applications from self-funded students and applicants seeking their own funding**
There may be some highly-competitive tuition fee waiver scholarships available for excellent candidates, but these are very limited and will only cover a portion of the tuition fees. The successful candidates would need to demonstrate that they can cover their own living costs through the whole duration of their studies.
For more information about available PhD projects in the department of Biology and Biochemistry at the University of Bath, please see: http://www.bath.ac.uk/bio-sci/postgraduate/phd-projects/
There may be some highly-competitive tuition fee waiver scholarships available for excellent candidates, but these are very limited and will only cover a portion of the tuition fees. The successful candidates would need to demonstrate that they can cover their own living costs through the whole duration of their studies.
For more information about available PhD projects in the department of Biology and Biochemistry at the University of Bath, please see: http://www.bath.ac.uk/bio-sci/postgraduate/phd-projects/
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