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Prof Jozsef Baranyi
No more applications being accepted
Competition Funded PhD Project (European/UK Students Only)
About the Project
Systems analysis of metabolism and growth functions in microbial pathogens is rapidly developing. The field of systems biology and microbial complexity has been enriched by genome-scale reconstruction of the biochemical reaction networks that underlie cellular processes. This network reconstruction process is based on a combination of genome sequence analysis, high-throughput network-wide and 'omics' data sets.
A reconstructed network can point to potential points of intervention where metabolic redundancy is minimal or where regulatory signals are indispensable for survival.
In this project we will focus on the network analysis of such biochemical systems. The project will include the development of a database and a modelling platform, and will aim to integrate transcriptomic data for specific applications. Numerical results will be used to answer biological questions. The project will take place in the Gut Health and Food Safety programme at the IFR, and will include interactions with mathematical and experimental scientists.
The ideal candidate for this challenging project is a physicist / mathematician with an affinity for life sciences, or bioinformatician / systems biologist with mathematical flare. The project will provide the student with in-depth analysis of genomic data deluge, with systems levels approaches, network science, dynamic modelling and complexity analysis. In particular, the candidate will need to be able to collect, interpret and synthesise in rigorous fashion information from in-house and online databases and is expected to develop his/her own modelling tools for analysing complex networks.
In keeping with the postgraduate training policy of the Biotechnology and Biological Sciences Research Council (BBSRC) all students recruited onto this programme will be required to undertake a three months internship during the second or third year of their study. The internship will offer exciting and invaluable experience of work in an area outside of research, and full support and advice will be provided by a professional team from the UEA.
This project has been shortlisted for funding by the Norwich Biosciences Doctoral Training Partnership (DTP) – a collaboration between the Norwich Biosciences Institutes and the University of East Anglia. Shortlisted applicants will be interviewed as part of the Studentship Competition.
A reconstructed network can point to potential points of intervention where metabolic redundancy is minimal or where regulatory signals are indispensable for survival.
In this project we will focus on the network analysis of such biochemical systems. The project will include the development of a database and a modelling platform, and will aim to integrate transcriptomic data for specific applications. Numerical results will be used to answer biological questions. The project will take place in the Gut Health and Food Safety programme at the IFR, and will include interactions with mathematical and experimental scientists.
The ideal candidate for this challenging project is a physicist / mathematician with an affinity for life sciences, or bioinformatician / systems biologist with mathematical flare. The project will provide the student with in-depth analysis of genomic data deluge, with systems levels approaches, network science, dynamic modelling and complexity analysis. In particular, the candidate will need to be able to collect, interpret and synthesise in rigorous fashion information from in-house and online databases and is expected to develop his/her own modelling tools for analysing complex networks.
In keeping with the postgraduate training policy of the Biotechnology and Biological Sciences Research Council (BBSRC) all students recruited onto this programme will be required to undertake a three months internship during the second or third year of their study. The internship will offer exciting and invaluable experience of work in an area outside of research, and full support and advice will be provided by a professional team from the UEA.
This project has been shortlisted for funding by the Norwich Biosciences Doctoral Training Partnership (DTP) – a collaboration between the Norwich Biosciences Institutes and the University of East Anglia. Shortlisted applicants will be interviewed as part of the Studentship Competition.
Funding Notes
Funding for PhD studentships from BBSRC is available to successful candidates who meet the UK Research Council eligibility criteria including the 3-year residency requirements in the UK. These requirements are detailed in the BBSRC eligibility guidelines (http://www.bbsrc.ac.uk/web/FILES/Guidelines/studentship_eligibility.pdf). In most cases UK and EU nationals who have been ordinarily resident in the UK for 3 years prior to the start of the course are eligible for a full-award. Other EU nationals may qualify for a fees only award. All candidates should check the BBSRC eligibility guidelines to confirm their eligibility for funding.
The current stipend for 2012/13 is £13,590 per annum.
The current stipend for 2012/13 is £13,590 per annum.
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