 |
 |
|
||||||||||||||||||
 | ||||||||||||||||||
| Effector and regulatory function of NK cells in experimental leishmaniasis | ||||||||||||||||||
NK cells are well known for their cytotoxicity and IFN-gamma production, and the important host protective role that they play during the innate response to infection. Largely, these responses are regulated by pro-inflammatory cytokines such as IL-12 and IL-18. Recent evidence, however, suggests that NK cell differentiation, like that of CD4+ T cells, may also lead to be diverse functional subsets of NK cells, but little is known of how functional diversity in NK cells develops or how these subsets exert their effects in vivo. We have recently shown that following Leishmania donovani infection, NK cells acquire the capacity to produce IL-10 and augment parasite survival. The aim of this project is to identify the molecular signals (e.g. cytokines, costimulatory molecules and/or NK receptors) responsible for the development of regulatory function in murine NK cells. The project will involve the use of in vitro and in vivo (including 2-photon microscopy) approaches to understand NK cell function and will provide extensive training in cellular and molecular immunology. Funding Notes This research project is one of a number of projects in the department. It is in competition for funding with the other projects. Usually the project which receives the best applicant will be awarded the funding. The funding is available to citizens of a number of European countries (including the UK). In most cases this will include all EU nationals. However full funding may not be available to all applicants. |
||||||||||||||||||
|
Research Assessment Exercise (RAE) 2008 Results
Do you like the look of this project? Select an option below to request more information from the provider:  Send an application enquiry  Give them a call  |
||||||||||||||||||
|