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| The interactive impact of apoE genotype and diet composition on the inflammatory process | ||||||||||||
The apolipoprotein E (apoE) genotype is known to be a significant determinant of cardiovascular disease (CVD) and Alzheimer’s disease (AD) risk, with a higher incidence in apoE4 carriers (25% population). However, there is a paucity of information regarding the physiological and molecular mechanisms underlying this genotype-disease association. Although it is likely to be in part due to the higher levels of blood lipids (LDL-cholesterol and triglycerides) in this genotype subgroup, recent research in our laboratory is indicating that a pro-inflammatory status, relative to the wild type E3/E3 genotype, may also make a significant contribution. The programme of work in this PhD studentship will extend these initial findings with a number of methodologies, which will include human studies, and cell culture and molecular techniques, employed. Furthermore the project will investigate the potential of dietary antioxidant and anti-inflammatory components to counteract the pro-inflammatory phenotype associated with the apoE4 genotype. It is envisaged that the work will make a significant contribution to the current understand of the basis for the association between an apoE4 genotype and chronic disease. Furthermore in an era where there is a focus on a move towards more personalised approaches to dietary recommendations, it is hoped the work will help identify which dietary strategies could be targeted to E4 individuals Funding Notes Stipend of £13,590 per annum (2010/11), UK/EU fees and some appropriate training costs. Applicants should hold a 2:1 degree or above or a master's degree in Nutrition, Biochemistry, Genetics, Physiology, Biological Sciences, other appropriate degrees will be considered. Those applicants whose first language is not English must demonstrate evidence of appropriate English language proficiency, normally defined as a minimum IELTS score of 6.5 (Overall Band Score) with 6.5 in all elements or equivalent 1. Carvalho-Wells AL, Jackson KG, Gill r, Olano-Martin E, Lovegrove JA, Williams CM, Minihane AM. Interactions between age and apoE genotype on fasting and postprandial triglycerides levels. Atherosclerosis EPub ahead of print. 2. Boesch-Saadatmandi C, Niering J, Minihane AM, Wiswedel I, Gardeman A, Siegfried Wolffram, Rimbach G. Impact of apolipoprotein E genotype and dietary quercetin on paraoxonase 1 status in apoE3 and apoE4 transgenic mice. Atherosclerosis In Press. 3. Jofre-Monseny L, Loboda A, Wagner AE, Huebbe P, Boesch-Saadatmandi C, Jozkowicz A, Minihane, AM, Dulak J, Rimbach G. Effects of apoE genotype on macrophage inflammation and heme oxygenase-1 expression. Biochemical Biophysical Research Communications, 2007;25:319-324. 4. Rimbach G, Minihane AM. Nutrigenetics and personalised nutrition: how far have we progressed and are we likely to get there? Proceedings of the Nutrition Society, 2009;68:162-172. 5. Jofre-Monseny L, Minihane AM, Rimbach G. The associations and potential means of modifying the impact of an apoE genotype on oxidative stress, inflammation and disease risk. Molecular Nutrition & Food Research 2008;52;131-145. |
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