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| Determining mitochondrial DNA deletions in mesenchymal stem cells to optimise therapies for the ageing skeleton. | ||||||||||||||||||
Mesenchymal stem cells (MSCs) may be used in cell-based therapies to treat degenerative disorders associated with the ageing skeleton. Cells typically suffer increasing levels of oxidative stress as a consequence of ageing and during growth in vitro. This means that MSCs extracted from older people and expanded for therapies will have limited therapeutic value. Oxidative stress induces mitochondrial DNA (mtDNA) deletions, which is a key causative event in cell ageing and these deletions are randomly distributed in cells within a tissue. This project aims to identify and isolate MSCs with low mtDNA damage from aged donors to optimise clinical outcome. Funding Notes This research project is one of a number of projects in the department. It is in competition for funding with the other projects. Usually the project which receives the best applicant will be awarded the funding. The funding is available to citizens of a number of European countries (including the UK). In most cases this will include all EU nationals. However full funding may not be available to all applicants. |
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Research Assessment Exercise (RAE) 2008 Results
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