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| HSPGs and cell migration | ||||||||||||||||||
During the progression of cancer, cells gain the ability to migrate to form new tumours in other parts of the body. This ability to migrate is also found in normal cells during embryonic development, for instance in neural crest cells (NCC) and the haemangiogenic lineage. A better understanding of the cues that allow normal cells to migrate during embryogenesis will underpin efforts to impair the ability of cancer cells to do the same during tumour progression. This project takes advantage of the fact that cells in these lineages are easily accessible in Xenopus embryos and that powerful techniques including gene knock-down and over-expression are simple to do together with lineage labelling, embryological grafting and imaging of the migrating cells in vivo. Our hypothesis is that the presence or absence of the enzymes Sulf1 and 6-OST modifies the structure of local HSPGs to direct NCC migration, possibly through modifying cellular response to FGF signalling. Funding Notes This research project is one of a number of projects in the department. It is in competition for funding with the other projects. Usually the project which receives the best applicant will be awarded the funding. The funding is available to citizens of a number of European countries (including the UK). In most cases this will include all EU nationals. However full funding may not be available to all applicants. |
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Research Assessment Exercise (RAE) 2008 Results
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