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We have 63 BBSRC PhD Projects, Programmes & Scholarships

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BBSRC PhD Projects, Programmes & Scholarships

We have 63 BBSRC PhD Projects, Programmes & Scholarships

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Understanding the role of pigmentation in retinal and vision development

University of Leicester School of Psychology and Vision Sciences
Establishing structure-function correlations in vision development  . The aim of this project is to develop methods to study the relationship between pigmentation and vision development in humans and zebrafish.  . Read more
 Supervisors: Dr M Thomas, Dr W Norton, Dr J McDearmid
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Nuclear and transcriptional dysregulations during cellular senescence

University of Leicester Molecular and Cell Biology
Cellular senescence, which is characterised by a proliferation arrest, is a driver of ageing (1). Several stresses can induce cellular senescence, including persistent DNA damage, telomere dysfunction, and oncogene activation. Read more
 Supervisors: Dr MT Tellier, Dr Y Markaki
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Obtaining insights into how a signalling hub protein Ras activates multiple effectors

University of Leicester Molecular and Cell Biology
The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. They are highly conserved from yeast to humans, highlighting their fundamental biological roles. Read more
 Supervisors: Dr K Tanaka , Dr R Mahen
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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The Role of Reactive Sulfur Species in the Ageing Heart

University of Leicester Molecular and Cell Biology
Second Supervisor. Prof Melanie Madhani, University of Birmingham. Background . Ageing is a natural and complex biological process that involves the gradual deterioration of cells, tissues, and organ systems over time, thus leading to an increased susceptibility to diseases and mortality. Read more
 Supervisor: Dr C Switzer
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Unlocking the Secrets of Genome Regulation through cryo-EM

University of Leicester Molecular and Cell Biology
Are you an ambitious spirit, ready to make breakthrough discoveries at the frontier of epigenetics? Dive deep into the fascinating world of eukaryotic genomes with us! . Read more
 Supervisors: Dr T Schalch, Dr AC Chaplin
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Using measures of eye movements and EEG to understand effects of cognitive ageing on reading

University of Leicester School of Psychology and Vision Sciences
Healthy ageing is associated with reductions in visual and cognitive abilities that are required for many activities of daily life (e.g., reading, navigation, object-finding). Read more
 Supervisors: Prof K Paterson, Dr A Pagán
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Molecular level understanding of Mycobacterium tuberculosis

University of Leicester Department of Respiratory Sciences
Mycobacterium tuberculosis has evolved to survive and replicate inside macrophages. The project will investigate the molecular mechanisms underpinning adaptation to this specialised intracellular niche. Read more
 Supervisors: Dr H O'Hare, Dr N Garton
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Failures to detect language errors during older age: Evidence of cognitive decline?

University of Leicester School of Psychology and Vision Sciences
Healthy ageing is associated with well-recognised cognitive decline across multiple domains from age 50 onwards (e.g., working memory, processing speed). Read more
 Supervisors: Dr V McGowan, Dr S Gunn
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Epigenetics of early human development: From molecular mechanisms to regenerative medicine

University of Leicester Molecular and Cell Biology
Ever wondered how nature maintains balance of gene expression between sex chromosomes? Well, the 46th chromosome of XX females, the second X, has to be switched off. Read more
 Supervisors: Dr Y Markaki, Dr T Schalch
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Epigenetic ageing and calorie restriction in an insect model system

University of Leicester Department of Genetics and Genome Biology
This project will help establish an insect model for epigenetic ageing, by analysing the effects of calorie restriction on chronological and epigenetic aging in an important insect model, Nasonia vitripennis, extending our discovery of an epigenetic clock in Nasonia. . Read more
 Supervisors: Prof E Mallon, Dr K Chen
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Understanding centrosome function in the human airway

University of Leicester Molecular and Cell Biology
Breathing sustains our life and is also important for our quality of life. Inside the lung, billions of hair-like structures called cilia beat a million times a day to promote a process called mucociliary clearance. Read more
 Supervisors: Dr R Mahen, Prof EH Hollox
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Investigating the role of SUMOylation in meiotic recombination and chromosome segregation in Arabidopsis

University of Leicester Department of Genetics and Genome Biology
Post-translational modifications of proteins such as phosphorylation, methylation and acetylation have been extensively studied in eukaryotes and now the Small Ubiquitin modifier (SUMO) is gaining attention for its importance in fundamental biological roles. Read more
 Supervisors: Dr J Higgins, Dr D Guttery
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Unlocking the genetic potential of barley by modulating recombination

University of Leicester Department of Genetics and Genome Biology
Barley is a major worldwide crop used for malting and animal feed. However, breeding new varieties is constrained by the frequency of genetic crossovers (1-3 crossovers per chromosome pair) and their distribution (biased towards the chromosome ends) that underpin crop improvement1,2. Read more
 Supervisors: Dr J Higgins, Dr D Guttery
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Enhancing meiotic recombination in wheat by modulating RECQ helicases

University of Leicester Department of Genetics and Genome Biology
Wheat accounts for 20% of the calories and protein consumed by humans and is the largest crop in the UK, but yields have plateaued and are susceptible to decline due to extreme weather conditions. Read more
 Supervisors: Dr J Higgins, Dr D Guttery
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Dissecting the interplay of extracellular vesicle signalling and tryptophan metabolism in schizophrenia pathogenesis

University of Leicester Department of Genetics and Genome Biology
L-kynurenine (KYN) and kynurenic acid (KYNA) are metabolites of the kynurenine pathway (KP) of tryptophan degradation and have been found to be increased in the brains of patients with schizophrenia. Read more
 Supervisor: Prof F Giorgini
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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