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PhD Projects, Programmes & Scholarships

We have 3,188 PhD Projects, Programmes & Scholarships

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Bacterial lipid bodies: Targeting pathogen fat reserves for infection control

Bacterial lipid bodies (LBs), also known as intrabacterial lipid inclusions or lipid droplets, are intracellular accumulations of neutral lipids, such as triacylglycerol (TAG) and wax esters. Read more
 Supervisors: Dr N Garton, Prof G Mukamolova
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Scalable and Interpretable Time Series Machine Learning for Industrial Systems

Modern manufacturing, engineering and automotive systems generate vast volumes of time series data at high speed. Read more
 Supervisors: Dr MB Middlehurst, Prof S Konur
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Evaluating the genetic basis and evolution of virulence and antimicrobial drug resistance in Helicobacter pylori in a populational model

Project background. Characterization of the genetic variation of bacterial species and the evolutionary mechanisms leading to that variation is crucial for understanding bacterial adaptation to their host environments, as well as the evolution of phenotypes such as virulence and antimicrobial drug resistance (AMR). Read more
 Supervisors: Dr S Beleza, Dr K Schilcher, Dr FF Freund
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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AI for Understanding and Safeguarding Online Social Networks: Mapping Dynamics and Countering Threats

Online social networks have become central to how people share news, form opinions, and connect with communities, shaping both social behaviour and public perception on a global scale. Read more
 Supervisors: Dr A Zareie, Prof S Konur
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Non-tuberculous mycobacteria in agrifood and the environment at the human-animal-ecosystems interface: resistance, persistence and longevity

Second Supervisor. Dr Marie Kirby, Agriculture and Environment, Harper Adams University. Project Outline. Environmentally resident mycobacteria are important animal pathogens known to infect cattle, pigs, fowl, sheep and most other commercially valuable livestock. Read more
 Supervisor: Dr J Pearl
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Development of a Patient-Specific Corneal Digital Twin Based on Topographic Imaging for Contact Lens Fitting and Future Corneal Interventions

This PhD project aims to develop a patient-specific corneal digital twin derived exclusively from routinely acquired corneal topography and tomography data. Read more
 Supervisors: Prof R Qahwaji, Dr I Ghafir
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Exploring Weather Events Affecting The Health and Emergency intensive care admissions of children using Routine data: the WEATHER study

Background. Climate change and air pollution pose a significant global challenge, disproportionately affecting the health and lives of children.1 Despite lifelong exposure, little is known about how weather impacts children, even though air pollution, which is closely linked with weather, harms every organ in the body. Read more
 Supervisors: Dr S.E. Seaton, Prof J Manning, Dr TL Lucas
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents

  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more
 Supervisors: Prof R Falconer, Dr S Shnyder
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

  Research Group: Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more
 Supervisors: Prof R Falconer, Prof P Loadman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Polysialyltransferases as a target in metastatic cancer

  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases. Read more
 Supervisors: Prof R Falconer, Dr S Shnyder
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Mapping cardiac microstructure in aortic stenosis and diabetes using diffusion MRI and machine learning

Heart failure remains one of the leading causes of hospitalisation and death worldwide. Two of its most important causes, type 2 diabetes and aortic stenosis, both lead to thickening and stiffening of the heart muscle, but the microscopic processes underlying these changes are not fully understood. Read more
 Supervisors: Dr M Afzali, Prof G McCann, Dr A Singh, Dr TP Pearce
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Aldehyde dehydrogenase expression and function in cancer stem cells

Aldehyde dehydrogenases (ALDHs) catalyse the oxidation and detoxification of reactive endogenous and exogenous aldehydes into carboxylic acids via NAD+ coupled reduction. Read more
 Supervisors: Prof K Pors, Dr S Swaroop, Dr A Ruiz Estrada
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Development of chemical tools and bioactive compounds to explore the importance of enzyme activity in cancer diseases

Diversity-oriented synthesis (DOS) is a modern chemical methodology, which aims to synthesise small molecules that cover new chemical space with the possibility of finding unexplored biological targets or pathways that may be important for disease progression. Read more
 Supervisors: Prof K Pors, Dr V Jha, Dr Muhammad Wahajuddin
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Our agricultural future: Crop genomics, biodiversity and phylogenetics in the context of evolution of genome organization, epigenetics, and phylogenetics

At the forefront of agricultural genetics, the fundamental objectives of the project aim to define biodiversity and relationships of agricultural species and their wild relatives, leading to prospects for developing new genotypes and approaches to increase farm sustainability and ensure food security. Read more
 Supervisor: Prof P HESLOP-HARRISON
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Development of antibody-drug conjugates (ADCs) for oncology indications

A major challenge in cancer therapy is to develop therapeutic agents that selectively target tumour cells but are not harmful to normal tissue. Read more
 Supervisors: Prof K Pors, Dr Muhammad Wahajuddin, Prof R Falconer
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Consequences of CD20 ligation in diffuse large B cell lymphoma

The addition of the monospecific chimeric CD20 antibody rituximab to chemotherapy transformed outcomes for patients with DLBCL without additional significant toxicities (1). Read more
 Supervisors: Dr H Walter, Dr Y Markaki, Prof M J S Dyer
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating genetic and circadian rhythm effects on radiotherapy side effects for breast cancer

Project. Radiotherapy is an effective form of cancer therapy that targets high energy irradiation to the tumour volume, resulting in destruction of cancer cells and improved survival. Read more
 Supervisors: Dr C J Talbot, Dr TR Rattay
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Environmentally induced DNA methylation – a passive biomarker or driver of genetic mutation?

Project. DNA methylation is a core epigenetic mechanism involved in regulating gene expression, mediating environmental responses, and potentially influencing genome evolution. Read more
 Supervisor: Dr H Marshall
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Unlocking the Secrets of Ageing: Exploring Epigenetic Clocks in the Jewel Wasp Nasonia vitripennis

Why do we age, and can that process be slowed? This project explores one of biology’s most fascinating and urgent questions by studying how tiny insects can reveal universal rules of ageing. Read more
 Supervisors: Prof E Mallon, Dr K Chen
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Identifying the neurogenetic network underlying visually-driven sleep

Drosophila Sleep Neurogenetics Laboratory at University of Leicester is open to supervise enthusiastic students for their PhD research in the area related to neurogenetic mechanisms underlying visually-driven sleep. Read more
 Supervisors: Dr K Chen, Dr E Rosato, Dr R Feuda
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Urban Building Cluster Morphology Optimization based on Accumulative Heat Exhaustion from Clustered Photovoltaic Systems on Urban Microclimate

This doctoral research project aims to conduct a focused, in-depth, and efficient investigation into the emerging scientific issue of the “clustered heat exhaust effect” associated with the largescale deployment of photovoltaic (PV) systems’ clusters. Read more
 Supervisor: Dr J Andric
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Digital Intelligent Conservation and Adaptive Use of Urban and Rural Heritage

Our project investigates how artificial intelligence and digital intelligence technologies can advance the conservation and adaptive reuse of urban and rural heritage in China. Read more
 Supervisor: Prof MA Schnabel
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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The Semantic Segmentation-Based Recognition Phase Components within the UHPC under normal and high temperature: Theory, Methodology and Application

The proposed research project aims to enhance the microscale structure-driven multiscale modeling framework for UHPC materials by incorporating advanced AI-driven image semantic segmentation technology for identifying phase composition based on digital images from microscale examinations. Read more
 Supervisor: Dr J Xia
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Exploration of novel molecular photoswitches

  Research Group: Kilian group
Research activities in Kilian group are centred on the design and synthesis of novel organophosphorus and heavier Group 15 (As, Sb, Bi) organoelement compounds. Read more
 Supervisor: Dr P Kilian
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Data-Driven Numerical Modelling of Materials for High-Temperature Nuclear and Energy Applications

Next-generation nuclear and fusion energy systems place unprecedented demands on structural and functional materials, which must operate reliably under extreme thermal, mechanical, and environmental conditions. Read more
 Supervisor: Dr G Torelli
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Numerical Simulation of Concrete Fracture under Extreme Conditions using Phase-Field Methods

Concrete structures in energy, industrial, and civil infrastructure are frequently exposed to demanding conditions, such as multiaxial mechanical stresses, fire-induced thermal loading, and/or harsh environmental exposure. Read more
 Supervisor: Dr G Torelli
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Data-Driven Numerical Modelling of Material Behaviour for Finite Element Simulation

Modern infrastructure increasingly relies on materials whose composition varies due to local resources, alternative binders, and sustainability-driven formulations. Read more
 Supervisor: Dr G Torelli
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Combatting multi-drug resistant bacteria

Antimicrobial resistance (AMR) is a major crisis for human medicine. Globally, untreatable bacterial infections are increasing, leaving limited treatment options. Read more
 Supervisors: Dr M Buckner, Dr DW Cleary
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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PhD project: Next-generation hybrid PV-X technologies for the sustainable, independent provision of solar heat, power, clean water, fuels and other renewable vectors

The uptake of technologies that can harness solar energy to cater to diverse energy demands in buildings has been increasing markedly. Read more
 Supervisor: Dr C Markides
 Year round applications  PhD Research Project  Funded PhD Project (UK Students Only)
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Machine Learning Quantum Phase Transitions via Topology- and Symmetry-aware AI

  Research Group: Applied Mathematics
This PhD project focuses on using topological data analysis (TDA) in machine learning (ML) to study (exotic) quantum matter systems defined on a lattice. Read more
 Supervisor: Dr M Fazzi
 Year round applications  PhD Research Project  Self-Funded PhD Students Only