Genomics and drug resistance in pathogenic yeasts

PhD position with the Butler group at University College Dublin. The pathogenic yeast Candida parapsilosis is one the most common causes of candidiasis worldwide. It is often transferred from the hands of healthcare workers, and it can transition from the gut to the bloodstream. Drug resistance is a particular problem. This project will use genomics and large-scale gene editing to characterise the basis of drug resistance. In particular, we will investigate the role of Copy Number Variations, and the potential effect of a novel mechanism of gene amplification. We will also sequence the genomes of hundreds of clinical and environmental isolates, and we will apply large-scale CRISPR-Cas9 editing. Students will join a structured PhD programme, obtaining training in infection biology, and in computational biology if interested. There will also be courses in public outreach and entrepreneurship. Training will be provided in state-of-the-art genomics approaches, including with in-house Illumina, minION and single cell genomics facilities. Students should have an interest in genomics, infection biology and/or bioinformatics.

A background and/or interest in computational biology or bioinformatics may be an advantage for one position. The second position is more suitable for students interested in microbiology/molecular biology/infection biology. Students should have a BSc or MSc (at least II.1 or equivalent) in a suitable area including Genetics, Microbiology, Biochemistry or similar.

The project will take place in the Conway Institute, University College Dublin. More details about the lab are available at http://butler.ucd.ie.

Students should start in October 2020, or as soon as possible after this date. Only EU/EAA/UK residents should apply.