[FSE Bicentenary PhD] Relocating with light – Photocatalytic functional group location editing for feedstock valorisation

We will develop innovative photocatalytic methods that move carbonyl groups from one site in a molecule to another – we call this location editing – thus dramatically changing the properties of a molecule. Thus, location editing will allow synthetic chemists to ‘hop’ from one family of molecules to another of higher value.

‘Functional groups’ – for example, carbonyl groups containing carbon-oxygen double-bonds – are key substructures that define the properties of molecules, including pharmaceuticals, agrochemicals, fragrances, and materials. Crucially, their location within a molecule is also critical in determining a molecule’s activity. To build important carbonyl compounds, synthetic chemists must work with a limited range of feedstocks. For example, malonic acid, is a versatile raw material used widely in chemical manufacturing and is a sustainable feedstock as it can be obtained from renewable sources using bio-based processes. If one of the carbonyl groups in malonates can be relocated, using our innovative location editing approach, then malonates can be converted atomeconomically, into another high value family, with very different properties, in a single, selective photocatalytic process. For example, selective relocation of a carbonyl group in malonate derivatives could allow access to adipates, highly valuable molecules otherwise derived from adipic acid, an even more important feedstock that is typically produced from petrochemical sources.

This PhD project builds on our world-leading expertise in samarium(II) diiodide-mediated radical chemistry and photocatalysis. Photocatalytic location editing will be extended to other functional groups and other relocations, thus providing a general way to valorise molecules. Collaborative computational studies will be used to understand the mechanism of photocatalytic location editing and the products of relocation will be used in expedient approaches to bioactive compounds for evaluation. The PhD project will deliver a unique training in contemporary synthesis and catalysis alongside an introduction to computational chemistry

Before you apply: We strongly recommend that you contact the supervisor(s) for this project before you apply. 

How to apply: To be considered for this project you’ll need complete a formal application through our online application portal. If you already have an applicant account this link will directly open an application for FSE Bicentenary PhD. If you don’t already have an applicant account, please follow the instructions here.

When applying, you’ll need to specify the full name of this project, the name of your proposed supervisor/s, details of your previous study, and names and contact details of two referees. You also need to provide a Personal Statement describing the motivation to apply to the project and your CV. Your application cannot be processed without all of the required documents, and we cannot accept responsibility for late or missed deadlines where applications are incomplete. 

Equality, diversity and inclusion: Equality, diversity and inclusion are fundamental to the success of The University of Manchester, and are at the heart of all of our activities. We know that diversity strengthens our research community, leading to enhanced research creativity, productivity and quality, and societal and economic impact. We actively encourage applicants from diverse career paths and backgrounds and from all sections of the community, regardless of age, disability, ethnicity, gender, gender expression, sexual orientation and transgender status. 

We also support applications from those returning from a career break or other roles. We consider offering flexible study arrangements (including part-time: 50%, 60% or 80%, depending on the project/funder). 

Eligibility: Applicants should have, or expect to achieve, at least a 2.1 honours degree or a master’s (or equivalent) in in Chemistry. Research experience in organic synthesis and catalysis is desirable.

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