Glial roles during brain development

The Fernandes lab studies how brains are built using the visual system of the fruit fly (Drosophila melanogaster) as a model system. In a developing brain, precursors must divide, know when to stop dividing, adopt distinct fates and then connect with appropriate partners. Although two cell types make up the brain, most research has focused until now on understanding how neurons regulate their development intrinsically. Our research focuses on how the other, under-studied cell type, called glia, can regulate these various aspects of neural development. For instance, glia are known to regulate neural stem cell proliferation by providing supportive niche signals, or act as neural stem cells themselves. We have shown that glia can also induce neuronal differentiation and that this can be a strategy for synchronising development across distant brain regions. Nonetheless, we are only just beginning to appreciate the diverse roles that glia play during development and much remains to be uncovered. In addition to cataloguing the full repertoire of glial functions, we also aim to understand how they do so mechanistically. See the lab website for more details: www.fernandesflylab.com

To decipher how glia sculpt the developing brain, the lab employs sophisticated Drosophila genetics, immunohistochemistry, molecular techniques, confocal imaging and multiphoton live-imaging. Possible projects include:
1. Understanding how signals from glia impart unique neuronal identities.
2. Defining the cues that regulate a glia-to-neuron transition.
3. Characterising glial diversity in the visual system.
4. Exploring glial involvement in neuroepithelial proliferation.

Candidates should have a 2:1 (or equivalent) degree or better in a suitable biomedical science-
related area, and a strong interest in developmental and neurobiology. Ideal candidates will have biomedical laboratory work experience. We also encourage candidates with knowledge of computational modelling methods (ODEs), however, this is not a requirement.

How to apply
To apply, or for additional information please contact Dr. Vilaiwan Fernandes ([Email Address Removed]) with a cover letter, CV and a brief statement of research interests. There is no formal closing date for applications but a student will be appointed as soon as a suitable, high quality candidate is identified.

Start date: January 2019 but flexible.