Uncertainty-aware structure-to-specificity modelling for generalizing transcription factor binding predictions from sparse mutational data
The University of Manchester
Division of Evolution, Infection and Genomics
AI_CDT_DecisionMaking. Details. Precise control of transcription is essential for engineering biological systems. TetR-family repressors are widely used in genetic circuits, but developing variants with new DNA-binding specificity remains largely empirical, requiring extensive testing. Read more
Supervisors: Dr M Lagator, Prof M Rattray, Prof S Lovell
4 December 2026
PhD Research Project
Competition Funded PhD Project (Students Worldwide)