We have 27 cell gene therapy PhD Projects, Programmes & Scholarships

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cell gene therapy PhD Projects, Programmes & Scholarships

We have 27 cell gene therapy PhD Projects, Programmes & Scholarships

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How do transcriptional kinases regulate cell cycle progression?

Project. Cyclin-dependent kinases (CDKs) are protein kinases performing essential functions by regulating cell cycle and RNA polymerase II transcription of protein-coding and non-coding genes. Read more
 Supervisors: Dr MT Tellier, Dr R Mahen
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Stochastic modelling and inference for live-cell gene expression time-series data to unravel the mechanisms of stem cell differentiation

  Research Group: Mathematical Biology Group
This project will develop statistical methodology for noisy time-series data and stochastic computational models to analyse live-cell imaging data provided by the lab of our collaborator Dr Cerys Manning at the University of Manchester. Read more
 Supervisors: Dr G Minas, Dr J Kursawe
 Year round applications  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Smart Switchable Sensors for On Demand Biosensing and Cell Therapy Monitoring

Cell and gene therapies are transforming medicine by enabling personalised treatments for patients with cancer and other life-threatening diseases. Read more
 Supervisor: Prof P Mendes
 Year round applications  PhD Research Project  Funded PhD Project (UK Students Only)
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Harnessing Regenerative Gene Therapy for the Treatment of Cystic Fibrosis Lung Disease

  Research Group: Nanomedicine and biotherapeutics
Cystic fibrosis (CF) is a chronic airways disease caused by mutations in a cAMP-dependent chloride channel called the cystic fibrosis transmembrane conductance regulator (CFTR). In the lungs, defective ion channel activity and mucus obstruction results in chronic cycles of infection and inflammation, with tissue damage leading to progressive lung function decline and premature death. Read more
 Supervisors: Prof L Martin, Prof C Taggart
 Year round applications  PhD Research Project  Funded PhD Project (UK Students Only)
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Human haematopoietic stem cells biology in health and disease

Group Leader. Professor Elisa Laurenti (Laurenti Group). Research Summary. Every day a trillion blood cells are produced in our body. Read more
 Supervisor: Prof E Laurenti
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Viral regulation of host cell signalling pathways

The study of human adenoviruses has been fundamental towards our understanding of many of the molecular pathways that underlie cellular processes such as cell growth and cell death. Read more
 Supervisor: Dr A S Turnell
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Liquid biopsy for early detection and disease monitoring of aggressive T-cell lymphomas

  Research Group: Cancer Sciences
Background. T-cell lymphomas are rare but highly aggressive blood cancers. Despite advances in cancer research, outcomes for patients with these diseases have seen little improvement in the past 30 years. Read more
 Supervisors: Dr MA Ahearne, Dr H Walter
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Mechanisms of Cancer Stem Cell Survival, Metastasis Formation and Immune Evasion in Cancer

Recent research suggests that cancer cells within a tumour represent a highly heterogeneous cell population. In particular many tumours contain small percentage of cells that share several characteristics with stem cells. Read more
 Supervisor: Prof D Widera
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Discovering Therapeutic Targets for ALS Using CRISPR-dCas9 Single-Cell Perturb-Seq in Patient-Derived Motor Neurons

Project Description. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no effective cure. Although several causal mutations (e.g. Read more
 Supervisor: Dr R Weatheritt
 Year round applications  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Reprogramming Human Envelope Proteins for Neuronal Genome Editing

Targeted delivery remains the principal bottleneck for therapeutic genome editing, particularly in the central nervous system where efficient delivery to defined neuronal populations remains challenging. Read more
 Supervisors: Dr JH Haldrup, Prof S Hyde, Prof C Rinaldi
 1 December 2026  PhD Research Project  Funded PhD Project (Students Worldwide)
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Haematological Malignancies

Group Leader. Dr Adam Wilkinson (Wilkinson Group). Research Summary. Haematopoietic stem cells (HSCs) are critical for human health and disease treatment. Read more
 Supervisor: Dr A Wilkinson
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Cardiac and skeletal muscle progenitor cells - driving regeneration ability by tryptophan metabolites

The School of Biomedical Sciences invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2026/27. Read more
 Supervisors: Dr A.J. Smith, Dr T.S. Bowen
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Molecular characterization of suicidal phage-resistance mechanisms in bacteria

Importance. The proliferation of antibiotic resistance (AMR) through horizontal-gene-transfer (HGT) is a formidable health challenge, accounting for 700,000 deaths annually1. Read more
 Supervisors: Dr A Koyamangalath Vadakkepat , Dr M Clokie
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating Pathogenic Mechanisms And Therapeutic Approaches For mtDNA Mutations In Cellular Models And Patients

Mutations in mitochondrial DNA (mtDNA) are the most common cause of inherited mitochondrial disease and are increasingly implicated in common age-related conditions including neurodegeneration. Read more
 Supervisors: Prof R Horvath, Prof M Minczuk, Dr J van den Ameele
 8 December 2026  PhD Research Project  Funded PhD Project (UK Students Only)
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Developing a Precision RNA Editing Platform for Therapeutic Applications

RNA editing is a natural and widespread post-transcriptional modification in mammalian cells, primarily involving adenosine to inosine (A-to-I) conversions mediated by ADAR enzymes, and cytosine to uridine (C-to-U) conversions facilitated by APOBECs. Read more
 Supervisors: Prof C Rinaldi, Prof S Sanders
 1 December 2026  PhD Research Project  Funded PhD Project (Students Worldwide)