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inflammatory bowel disease PhD Projects, Programs & Scholarships

We have 13 inflammatory bowel disease PhD Projects, Programs & Scholarships

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  Investigating the molecular mechanism of inflammatory bowel disease
  Dr K Erdmann
Application Deadline: 23 January 2019
Cohn’s disease together with ulcerative colitis (UC) are the two main variations of inflammatory bowel disease (IBD). 2.5-3 million people in Europe are affected by inflammatory bowel disease with a direct healthcare cost of 4.5-6 billion Euro per year.
  Intestinal Immunology: exploring disease associated colonic mesenchymal populations, investigating molecular determinants of their evolution and function in barrier breakdown in IBD
  Prof A Simmons, Dr H Koohy
Application Deadline: 26 July 2019
We study how the intestinal immune system functions to enable the symbiotic relationship with the intestinal microflora required for health.
  Characterising the faecal virome in Crohn’s disease patients with known NOD2 variants compared to matched controls without gastrointestinal disease (ref: SF18/APP/Bridge)
  Dr SH Bridge
Applications accepted all year round
The human virome includes viruses that infect host cells and viruses that infect bacteria, and impacts on health and disease independently of classical viral disease.
  Exploring aberrant inflammasome activation in chronic granulomatous disease
  Dr S Webster, Prof C E Bryant
Applications accepted all year round
This project will test the hypothesis. Aberrant inflammasome activation can be caused by mitochondrial ROS mediated NLRP3 inflammasome activation.
  Deep Phenotyping of Crohn’s Patients using a Precision Imaging Approach to Identify Drivers and Stratify Risk of Wasting and Myosteatosis
  Dr G Moran, Prof P Greenhaff, Prof P Gowland, Dr M Brookes
Application Deadline: 25 February 2019
Up to 75% of hospitalized Crohn’s disease (CD) patients are malnourished and as many as 50% are in negative nitrogen balance(1), but variations in muscle mass and quality in this group is poorly characterised as are the drivers of such pathophysiology.
  Developing a three-dimensional research model of neutrophil-mediated tissue destruction during inflammation
  Dr J Hirschfeld, Prof I L C Chapple, Dr M Grant
Applications accepted all year round
Background. The proposed research has the goal to develop a novel 3D model to measure and visualise tissue destruction mediated by migrating neutrophils in vitro.
  Interdisciplinary investigation of a large effect of sulfasalazine on HbA1c
  Dr G Rena, Prof E Pearson
Applications accepted all year round
The anti-inflammatory drug sulfasalazine, which is used in rheumatoid arthritis and inflammatory bowel disease, was reported earlier to suppress HbA1c in a small cohort of patients [1].
  Regulation of intestinal immune homeostasis and inflammation by the gut microbiota
  Dr E Mann, Dr M Travis
Applications accepted all year round
Our immune system must fight harmful pathogens, but remain silent against harmless substances such as the trillions of bacteria found in the gut that are beneficial for health.
  Functional Selectivity and the Regulation of Receptor-Activated Signaling Pathways
  Dr G Cottrell, Dr D Widera, Dr S Amadesi, Dr A McNeish
Applications accepted all year round
The molecular mechanisms that regulate receptors and receptor-activated signaling pathways in the cardiovascular and nervous systems are complex.
  New Drugs, New Biology, Tomorrow’s Therapies: Design and Characterisation of Novel Cannabinoid Ligands
  Dr N Grimsey
Applications accepted all year round
Compounds derived from Cannabis sativa, termed “cannabinoids”, primarily exert their effects via two G protein-coupled receptors (GPCRs), Cannabinoid Receptors 1 and 2 (CB1 and CB2).
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