We have 97 medical research council PhD Projects, Programmes & Scholarships

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medical research council PhD Projects, Programmes & Scholarships

We have 97 medical research council PhD Projects, Programmes & Scholarships

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Structural and cellular approaches to understand microtubule motors

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
Transport of organelles, RNAs and proteins is essential for the development, health and function of neurons.Defects in the microtubule motors that drive the transport is linked to neurodegenerative and developmental diseases and the transport process is frequently hijacked by viruses. Read more
 Supervisor: Dr A Carter
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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The macromolecular basis of nuclear remodelling in humans

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
Our lab focuses on understanding the processes which lead to a reshaping of the nuclear compartment in health and disease. The nucleus is continuously reshaped by the cytoskeletal filaments that surround it. Read more
 Supervisor: Dr M Allegretti
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Closing the loops: Unleashing the poteintial mTORC2.

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
mTORC2 can integrate multiple activating influences to positively influence anabolism, survival and cytoskeletal remodelling. We have characterised a positive feedback loop between mTORC2 and AKT and have shown that mTORC2 has a great potential for activation that has been overlooked in previous work. Read more
 Supervisor: Dr R Williams
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Non-protein ubiquitylation in infection and physiology

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
Ubiquitylation is essential for eukaryotic life. Until recently, proteins were the only substrates known to be modified with ubiquitin. Read more
 Supervisor: Dr F Randow
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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The life cycle of ecDNA

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
A major focus of the lab is understanding the links between replication and mutagenesis (1‑4). Extrachromosomal DNA (ecDNA) circles are present in a substantial proportion of cancers and frequently harbour oncogenes that drive tumour proliferation (5). Read more
 Supervisor: Dr J Sale
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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TRIM21 degradation of viruses and aggregates

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
TRIM21 is the cytosolic E3 ligase and antibody receptor responsible for intracellular antibody immunity. Unlike other ubiquitin ligases, TRIM21 doesn’t have a defined substrate but is directed towards its targets by antibodies. Read more
 Supervisor: Dr L James
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Replicating RNA with RNA

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
A critical event in the origin of life is thought to have been the emergence of an RNA molecule capable of self-replication as well as mutation, and hence evolution towards ever more efficient replication. Read more
 Supervisor: Dr P Holliger
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Pathological protein assembly in neurodegenerative diseases

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
Neurodegenerative diseases are one of the greatest health challenges facing our society. This large group of diseases is characterised by the pathological assembly of specific proteins into amyloid filaments in the central nervous system. Read more
 Supervisor: Dr B Falcon
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Connectomics across sexes, species and states

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
Neuroscience in the fly and beyond is being transformed by the availability of connectomes, synaptic resolution wiring diagrams. We have played leading roles in two large collaborations that have recently generated and analysed separate (female) brain and (male) nerve cord connectomes for the fly. Read more
 Supervisor: Dr G Jefferis
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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AMPA receptor structure and function

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
Excitatory synapses are the principal sites at which information is integrated and stored in the brain, yet we still lack a molecularly resolved understanding of how their strength and plasticity are determined. Read more
 Supervisor: Dr I Greger
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Effect of activity in neural circuit development

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
Neuronal activity is necessary for the establishment of correctly functioning neuronal circuits in development. Read more
 Supervisor: Dr A Cardona
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Structure-function analysis of stress signaling

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
Our lab studies stress signaling and pioneers strategies that harness such pathways to enhance cellular resilience, a modality generically applicable to improve fitness in diverse diseases, including the age-related neurodegenerative diseases. Read more
 Supervisor: Dr A Bertolotti
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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The molecular architecture of neurotransmission

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
Chemical synapses are cellular connections that define the organization and function of neuronal circuits and, as a result, the fundamental ability of the brain to acquire, process and store information. Read more
 Supervisor: Dr R Aricescu
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Where do cells go in the human embryo?

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
The first two weeks of human development transform a single-cell into a complex, bilaminar embryo. During this critical period, cells acquire distinct identies and organise into increasingly complex tissue architectures. Read more
 Supervisor: Dr M Shahbazi
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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How the embryo gets its shape

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
The McDole lab seeks to understand how complex 3D structures in the embryo are sculpted from initially homogenous cell populations. Read more
 Supervisor: Dr K McDole
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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