Molecular Pharmacology of N-Methyl-D-aspartate glutamate receptors
Dr P Chen
Applications accepted all year round
Fast neuronal communication at synaptic contacts relies on neurotransmitter release from the presynaptic terminal and the majority of excitatory neurotransmission within the mammalian central nervous system is mediated by the neurotransmitter glutamate.
Identification and characterisation of protein depalmitoylases
Dr J Greaves, Prof M Wheatley
31 May 2019
S-acylation (palmitoylation) is an essential post-translational modification (PTM) involving the reversible attachment of fatty acids, such as palmitic acid, onto the cysteine residues of proteins.
Targeting the P2X7 purinergic receptor in melanoma (STOKESLU19SF)
Dr L Stokes, Dr C Morris
31 May 2019
There is much research into trying to regain control of cell proliferation or cell death (apoptosis) in cancer. Different strategies exist to do this and a multitude of individual receptor targets are being identified in tumour cell lines and primary cells.
Using optogenetics to understand memory retrieval in models relevant to Alzheimer’s disease
Centre for Clinical Brain Sciences
Dr S Wang, Dr K Horsburgh
30 April 2019
Memory dysfunction is a hallmark in Alzheimer’s disease (AD) that significantly affects the daily life in people living with AD. It remains debated whether memory deficits reflect an inability to store the information or an inability to retrieve information that is previously stored.