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The University of Manchester PhD Projects, Programmes & Scholarships
We have 275 The University of Manchester PhD Projects, Programmes & Scholarships
We have 275 The University of Manchester PhD Projects, Programmes & Scholarships
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Investigating the physio-chemical behaviour of fission products within nuclear grade graphite
It is now widely accepted that nuclear power has an integral role to play in the UK, if the ambitious targets of reaching net-zero are to be achieved. Read more
Photocatalytic editing of complex molecules
The development of molecular editing platforms, the process by which single atoms can be inserted or deleted selectively in or around a molecule’s skeleton, would be transformative to synthetic chemists across industry and academia for the streamlined development of new drugs. Read more
Machine learning to stratify psoriatic arthritis in children and adults
Psoriatic arthritis can have onset in child or adulthood, from infants to the elderly. It is a highly heterogenous disease, with features potentially affecting the joints, skin, nails and scalp. Read more
An evaluation of the role of excipients on the stability of lipid nanoparticles-based vaccines.
Covid vaccine based on lipid nanoparticles (LNP) have been the success story of the covid pandemic. Our group has been working on the long-term stability of liquid formulation of mRNA like LNP particles in collaboration with the industry. Read more
Is lyophilisation the way forward for lipid nanoparticles-based vaccines?
Covid vaccine based on lipid nanoparticles (LNP) have been the success story of the covid pandemic; however, as they are liquid formulation, these vaccines suffer from thermal instability. Read more
Deciphering the regulation of NKX2-5, a key transcription factor in heart development, to uncover the fundamental mechanisms of cardiac cell development from stem cells
Our understanding of cardiac cell development remains incomplete, specifically how the progenitor cells, which give rise to the heart, are programmed to acquire cardiac potential. Read more
Neuronal mechanisms of circadian timekeeping in the diurnal brain
The importance of circadian rhythms in our physiology and behaviour, such as our sleep-wake cycle, feeding schedule, hormone production, etc, to maintain health and wellbeing is well established. Read more
Dynamics of neurogenesis during spinal cord regeneration
About 1200 people a year are left paralysed in the UK due to a Spinal Cord Injury (or SCI). This is because injuries involving the central nervous system (CNS) have poor capacity to repair or regenerate. Read more
The fundamental requirements and components of translation factories for the co-ordinated production of key proteins and pathways in yeast
Understanding the mechanisms surrounding the coordinated production of protein in biotechnological organisms such as baker’s yeast (S. Read more
How substrates affect animal locomotion: from polar bears to sea
Animals move across complex environments with heterogenous terrain, where obstacles and variations in substrate, for example, ground compliance and roughness, are commonplace. Read more
Establishing the reliability and validity of digital tools to collect patient generated data
Background. The rise in consumer electronics ownership, such as smartphones and smartwatches, offers unique opportunities to collect granular subject-reported and passively collected research data via remote monitoring. Read more
Animal movement, route choice and energetic landscape in the Arctic
Scientific research has focused on the Arctic recently as this region is at high risk from the effects of climate change. However, a major challenge holds back our ability to understand the potential impacts of environmental change; our lack of knowledge about what animals do in the wild. Read more
Interrogating molecular switches that control developmental gene expression
The ability of cells and tissues to modulate rates of gene expression is critical for their ability to respond appropriately to cues during development, maintain normal function during ageing, and combat environmental insults and biological agents such as pathogens. Read more
Roles of negative transcriptional regulators in cancer cells.
The aim of the project is to investigate how factors involved in mRNA synthesis alter gene expression in human cells. . Read more
The mechanism of regulation of protein synthesis via eIF2 molecular complexes
Control of protein synthesis is critical for normal metabolism, development and responses to stress. One major pathway is called the integrated stress response (ISR) and centres on translational control of the general protein synthesis factor eIF2B via the phosphorylation of eIF2 [1,2]. Read more
