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Medical Research Council (Cambridge) PhD Projects, Programmes & Scholarships

We have 40 Medical Research Council (Cambridge) PhD Projects, Programmes & Scholarships

Exploiting Mitochondrial Genome Editing to Study Leber Hereditary Optic Neuropathy

Medical Research Council (Cambridge)

Mitochondrial Biology Unit

Background. Mutations in mitochondrial DNA (mtDNA) are the most common cause of inherited mitochondrial disease and are increasingly implicated in common age-related conditions including neurodegeneration. Read more

Supervisor: Prof M Minczuk

8 December 2026 PhD Research Project Funded PhD Project (UK Students Only)

Does perforin-2 form pores in two orientations?

Medical Research Council (Cambridge)

Laboratory of Molecular Biology

Perforin-2 (Mpeg1) is an ancient pore-forming protein of the membrane attack complex perforin/cholesterol-dependent cytolysin (MACPF/CDC) family with essential roles in immunity. Read more

Supervisor: Dr P Kozic

8 December 2026 PhD Research Project Competition Funded PhD Project (Students Worldwide)

Developing Precise Mitochondrial DNA Base Editors For Genome Therapy

Medical Research Council (Cambridge)

Mitochondrial Biology Unit

Background. Mutations in mitochondrial DNA (mtDNA) are the most common cause of inherited mitochondrial disease and are increasingly implicated in common age-related conditions including neurodegeneration. Read more

Supervisor: Prof M Minczuk

8 December 2026 PhD Research Project Funded PhD Project (UK Students Only)

Investigating Pathogenic Mechanisms And Therapeutic Approaches For mtDNA Mutations In Cellular Models And Patients

Medical Research Council (Cambridge)

Mitochondrial Biology Unit

Mutations in mitochondrial DNA (mtDNA) are the most common cause of inherited mitochondrial disease and are increasingly implicated in common age-related conditions including neurodegeneration. Read more

Supervisors: Prof R Horvath, Prof M Minczuk, Dr J van den Ameele

8 December 2026 PhD Research Project Funded PhD Project (UK Students Only)

Investigating Pathogenic Mechanisms And Therapeutic Targets For mtDNA Mutations

Medical Research Council (Cambridge)

Mitochondrial Biology Unit

Mutations in mitochondrial DNA (mtDNA) are the most common cause of inherited mitochondrial disease and are increasingly implicated in common age-related conditions including neurodegeneration. Read more

Supervisor: Dr A J Whitworth

8 December 2026 PhD Research Project Funded PhD Project (UK Students Only)

Hidden RAS conformations at the membrane

Medical Research Council (Cambridge)

Laboratory of Molecular Biology

RAS proteins are central molecular switches in human signalling and are among the most frequently mutated proteins in cancer. Read more

Supervisor: Dr JS Streit

8 December 2026 PhD Research Project Competition Funded PhD Project (Students Worldwide)

Protein aggregates and neurodegeneration

Medical Research Council (Cambridge)

Laboratory of Molecular Biology

To understand and ultimately treat neurodegenerative diseases characterised by protein aggregates, one must understand how these aggregates accumulate, how they become toxic to brain cells and the mechanisms which allow them to spread. Read more

Supervisor: Dr H McMahon

8 December 2026 PhD Research Project Competition Funded PhD Project (Students Worldwide)

Cell division in Asgard archaea

Medical Research Council (Cambridge)

Laboratory of Molecular Biology

Complex cells likely arose from the merger of an archaeal host cell with a bacterial cell some 2 billion years ago. As a consequence, many of the most conserved features of eukaryotic cell biology have their origins in archaea. Read more

Supervisor: Dr B Baum

8 December 2026 PhD Research Project Competition Funded PhD Project (Students Worldwide)

Connectomics of neural network plasticity

Medical Research Council (Cambridge)

Laboratory of Molecular Biology

Connectomics is the study of biological neural networks at synaptic resolution. The resulting wiring diagrams teach us how information is processed in animal brains, including perception and behaviour [1]. Read more

Supervisor: Dr ST Truckenbrodt

8 December 2026 PhD Research Project Competition Funded PhD Project (Students Worldwide)

How proteins fold on the ribosome in real time

Medical Research Council (Cambridge)

Laboratory of Molecular Biology

De novo protein folding is the fundamental process by which a polypeptide chain acquires its native conformation for the first time. Read more

Supervisor: Dr IB Bukvin

8 December 2026 PhD Research Project Competition Funded PhD Project (Students Worldwide)

Mechanism of transcription-coupled splicing

Medical Research Council (Cambridge)

Laboratory of Molecular Biology

Accurate gene expression in eukaryotic cells requires tight coordination between transcription and pre-mRNA splicing. During transcription by RNA polymerase II (Pol II), the spliceosome removes introns from nascent RNAs co-transcriptionally. Read more

Supervisor: Dr S Zhang

8 December 2026 PhD Research Project Competition Funded PhD Project (Students Worldwide)

DNA repair at stalled replication forks

Medical Research Council (Cambridge)

Laboratory of Molecular Biology

Large multiprotein complexes perform many essential functions in eukaryotic cells. My lab purifies, assays and determines structures of these macromolecular machines to understand their mechanisms. Read more

Supervisor: Dr L Passmore

8 December 2026 PhD Research Project Competition Funded PhD Project (Students Worldwide)

Reconstitution of cell division

Medical Research Council (Cambridge)

Laboratory of Molecular Biology

Background. During cellular division, most bacteria and archaea assemble a ring structure that coordinates the separation of mother and daughter cells. Read more

Supervisor: Dr J Lowe

8 December 2026 PhD Research Project Competition Funded PhD Project (Students Worldwide)

Structural and cellular approaches to understand microtubule motors

Medical Research Council (Cambridge)

Laboratory of Molecular Biology

Transport of organelles, RNAs and proteins is essential for the development, health and function of neurons.Defects in the microtubule motors that drive the transport is linked to neurodegenerative and developmental diseases and the transport process is frequently hijacked by viruses. Read more

Supervisor: Dr A Carter

8 December 2026 PhD Research Project Competition Funded PhD Project (Students Worldwide)

Machine learning for finding macromolecules in cells

Medical Research Council (Cambridge)

Laboratory of Molecular Biology

The aim of this PhD project is to develop computer software for in situ structural biology projects. Specifically, software tools for the identification of macromolecular complexes in cryo-EM/cryo-ET data sets collected on thinned human and budding yeast cells. Read more

Supervisor: Dr D Barford

8 December 2026 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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