We have 233 MRC PhD Projects, Programmes & Scholarships

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MRC PhD Projects, Programmes & Scholarships

We have 233 MRC PhD Projects, Programmes & Scholarships

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(MRC NW-DMS) From screen time to active time: Promoting physical activity and mental health in children and young people

Physical activity is important for mental and physical health, but many young people do not achieve recommended physical activity levels. Read more
 Supervisors: Dr JF Firth, Dr CF French, Prof R Elliott
 27 November 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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(MRC NW-DMS) Targeting pathogenic snRNA variants in neurodevelopmental disorders using antisense oligonucleotides.

Antisense oligonucleotides (ASOs) are short synthetic molecules that can be designed to bind selected RNA sequences and change how genes are expressed. Read more
 Supervisors: Dr PG Grzechnik, Prof S Banka
 27 November 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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(MRC NW-DMS) Uncovering plasmid-driven metabolic vulnerabilities to tackle multidrug resistant pathogens

Antibiotic resistance is a global health concern. Multidrug resistance (MDR) in bacterial pathogens is mediated by the gain of plasmids carry genes encoding resistance to clinically relevant antibiotics. Read more
 Supervisors: Dr R Hall, Dr J Hall, Prof M Brockhurst
 27 November 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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(MRC NW-DMS) Multimodal Foundation Models Linking Multi-Organ Development and Pan-Cancer Tissue Organisation

  Research Group: Division of Informatics, Imaging and Data Sciences
What if the same rules the body uses to build an organ are quietly reused by cancer? This project sets out to find out and to build the AI needed to investigate it. Read more
 Supervisors: Dr I Iqbal, Dr S Murtuza Baker, Prof A Sharrocks
 27 November 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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(MRC NW-DMS) Selective LGALS1 RNA Targeting in Blood Cancers using RiboTACs

  Research Group: Division of Cancer Sciences
Galectin-1, encoded by the LGALS1 gene, is a carbohydrate-binding protein that is frequently overexpressed in blood cancers and associated with poor clinical outcomes. Read more
 Supervisors: Dr K Batta, Dr D Wiseman, Dr S Butterworth
 27 November 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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(MRC NW-DMS) Electrographic and tear-fluid biomarkers of seizure risk after stroke with cerebral small vessel disease

Stroke is a leading cause of epilepsy in later life, but we cannot yet identify reliably who will develop seizures. Many people with a major stroke also have cerebral small vessel disease (cSVD), a common condition linked to hypertension that damages small blood vessels throughout the brain. Read more
 Supervisors: Dr R Wykes, Prof S Allan, Prof P Hamerlik
 27 November 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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(MRC NW-DMS) Investigating the role of microglial metabolic reprogramming in Alzheimer’s disease

  Research Group: Division of Neuroscience
Alzheimer’s disease (AD) is the most common cause of dementia, but we still do not fully understand why some people are at greater risk or why brain immune cells become dysfunctional. Read more
 Supervisors: Dr RN Ng, Prof T.W. Wang, Dr S Butterworth
 27 November 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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(MRC NW-DMS) Structural basis of endoplasmic reticulum-driven axon specification in health and disease

  Research Group: Division of Molecular and Cellular Function
Building a brain requires billions of neurons to grow, find each other and connect. This begins with a single decision inside each cell. Read more
 Supervisors: Dr S Bodakuntla, Prof M Lowe
 27 November 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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(MRC NW-DMS) Hungry adhesions: Do focal adhesions spatially organise metabolism to support cell mechanics?

How do cells deliver metabolic energy to the places where they need to do most mechanical work? Focal adhesions allow cells to grip their surroundings, generate force and move, but we do not know whether they also organise local metabolism. Read more
 Supervisors: Dr J.R.D Davis, Dr AB Byron, Dr C Ballestrem
 27 November 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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(MRC NW-DMS) Why do lymphocytes protect the fibrotic lung? Deep immunophenotyping and functional dissection of T-cell subsets in ILD

  Research Group: Division of Immunology, Immunity to Infection and Respiratory Medicine
Why do some patients with interstitial lung disease (ILD) stabilise while others rapidly deteriorate? ILD is a progressive, often fatal group of conditions with survival worse than many cancers. Read more
 Supervisors: Dr J Blaikley, Dr L Pearmain, Dr E Mann
 27 November 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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(MRC NW-DMS) From joint to lung: B cell-fibroblast crosstalk in rheumatoid arthritis-associated interstitial lung disease

  Research Group: Division of Immunology, Immunity to Infection and Respiratory Medicine
Rheumatoid arthritis (RA) can progress beyond the joint to cause interstitial lung disease (RA-ILD), a severe complication with a major impact on survival. Read more
 Supervisors: Dr M Menon, Prof MH Buch, Dr C.H. Hayton
 27 November 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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(MRC NW-DMS) Using Stem Cell-Brain Organoids to understand Kabuki Syndrome

The successful student will research an important incurable developmental condition affecting the brain with state of the art approaches at the interface of, stem cell biology, genomics and neuroscience. Read more
 Supervisors: Prof S Kimber, Prof S Banka, Dr G. Morris
 27 November 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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(MRC NW-DMS) Optimising data completeness in clinical prediction models incorporating high-frequency patient generated health data

  Research Group: Division of Informatics, Imaging and Data Sciences
Advances in digital technologies have made it possible to monitor patients remotely by collecting patient-generated health data (PGHD) through smartphones and wearable devices. Read more
 Supervisors: Dr S Bladon, Dr S Van der Veer, Prof W Dixon, Dr DJ Jenkins
 27 November 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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(MRC NW-DMS) The alveolar epithelium: a new reservoir for the emergence of drug resistance in A. fumigatus?

  Research Group: Division of Evolution, Infection and Genomics
Spores of the mould Aspergillus fumigatus cause >3,000,000 chronic and >300,000 invasive diseases annually worldwide. Invasive aspergillosis is the most fatal, with a 50% mortality rate, rising to >75% in certain cohorts, including people with Chronic Obstructive Pulmonary Disease (COPD). Read more
 Supervisors: Dr M Bertuzzi, Dr M Bottery
 27 November 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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(MRC NW-DMS ) Antibiotic use in hidradenitis suppurativa: prescribing patterns, treatment trajectories and antimicrobial treatment failure

Hidradenitis suppurativa is one of the most painful diseases in dermatology. It causes recurrent boils, abscesses and scarring in the armpits, groin and under the breasts, and affects around one in 130 people in the UK. Read more
 Supervisors: Dr Z Yiu, Prof D Ashcroft, Prof T Van Staa, Dr S Shoop-Worrall
 27 November 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)