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PhD Projects, Programmes & Scholarships

We have 5,870 PhD Projects, Programmes & Scholarships

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DNA repair at stalled replication forks

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
Large multiprotein complexes perform many essential functions in eukaryotic cells. My lab purifies, assays and determines structures of these macromolecular machines to understand their mechanisms. Read more
 Supervisor: Dr L Passmore
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Reconstitution of cell division

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
Background. During cellular division, most bacteria and archaea assemble a ring structure that coordinates the separation of mother and daughter cells. Read more
 Supervisor: Dr J Lowe
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Structural and cellular approaches to understand microtubule motors

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
Transport of organelles, RNAs and proteins is essential for the development, health and function of neurons.Defects in the microtubule motors that drive the transport is linked to neurodegenerative and developmental diseases and the transport process is frequently hijacked by viruses. Read more
 Supervisor: Dr A Carter
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Machine learning for finding macromolecules in cells

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
The aim of this PhD project is to develop computer software for in situ structural biology projects. Specifically, software tools for the identification of macromolecular complexes in cryo-EM/cryo-ET data sets collected on thinned human and budding yeast cells. Read more
 Supervisor: Dr D Barford
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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The macromolecular basis of nuclear remodelling in humans

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
Our lab focuses on understanding the processes which lead to a reshaping of the nuclear compartment in health and disease. The nucleus is continuously reshaped by the cytoskeletal filaments that surround it. Read more
 Supervisor: Dr M Allegretti
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Structures and mechanisms of the human replisome

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
Accurate genome duplication is essential for all forms of life. Read more
 Supervisor: Dr J Yeeles
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Closing the loops: Unleashing the poteintial mTORC2.

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
mTORC2 can integrate multiple activating influences to positively influence anabolism, survival and cytoskeletal remodelling. We have characterised a positive feedback loop between mTORC2 and AKT and have shown that mTORC2 has a great potential for activation that has been overlooked in previous work. Read more
 Supervisor: Dr R Williams
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Non-protein ubiquitylation in infection and physiology

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
Ubiquitylation is essential for eukaryotic life. Until recently, proteins were the only substrates known to be modified with ubiquitin. Read more
 Supervisor: Dr F Randow
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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The life cycle of ecDNA

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
A major focus of the lab is understanding the links between replication and mutagenesis (1‑4). Extrachromosomal DNA (ecDNA) circles are present in a substantial proportion of cancers and frequently harbour oncogenes that drive tumour proliferation (5). Read more
 Supervisor: Dr J Sale
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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TRIM21 degradation of viruses and aggregates

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
TRIM21 is the cytosolic E3 ligase and antibody receptor responsible for intracellular antibody immunity. Unlike other ubiquitin ligases, TRIM21 doesn’t have a defined substrate but is directed towards its targets by antibodies. Read more
 Supervisor: Dr L James
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Replicating RNA with RNA

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
A critical event in the origin of life is thought to have been the emergence of an RNA molecule capable of self-replication as well as mutation, and hence evolution towards ever more efficient replication. Read more
 Supervisor: Dr P Holliger
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Circuit basis of learning and action-selection

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
The overall goal of our research is to discover the circuit implementation of learning and action selection. Read more
 Supervisor: Dr M Zlatic
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Transforming Thoughts into Actions

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
How does the brain transform what we perceive into what we do? Even a simple action, such as stopping at a red light and moving again when it turns green, requires the brain to select relevant sensory information, form an intention, prepare an appropriate movement and execute it at the right moment. Read more
 Supervisor: Dr M Tripodi
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Neuropeptide networks in worms and octopus

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
In recent years, great efforts have been made to map the synaptic wiring diagrams of simple and complex nervous systems. However, chemical synapses, the connections used in most connectomics research, represent only one type of functionally important signalling between neurons. Read more
 Supervisor: Dr W Schafer
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Pathological protein assembly in neurodegenerative diseases

Medical Research Council (Cambridge)
Laboratory of Molecular Biology
Neurodegenerative diseases are one of the greatest health challenges facing our society. This large group of diseases is characterised by the pathological assembly of specific proteins into amyloid filaments in the central nervous system. Read more
 Supervisor: Dr B Falcon
 8 December 2026  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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