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PhD Projects, Programmes & Scholarships

We have 3,173 PhD Projects, Programmes & Scholarships

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MSc by Research: Trimming the fat - Identification of de-S-acylating enzymes from plants

Protein S-acylation is a reversible fatty acid-based post-translational modification of proteins. Read more
 Supervisors: Dr P Hemsley, Dr J Bos
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: Role and mechanism of the bacterial Type VI secretion system

Many species of bacteria use a contractile nanomachine known as the Type VI secretion system (T6SS) to deliver a wide range of toxic proteins, known as ‘effectors’, directly into neighbouring cells. Read more
 Supervisor: Dr S Coulthurst
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: Identifying microbiota responsible for longevity and health

Gut microbiome is the community of microbes living together in the gastrointestinal tract of an animal. They provide specific functions to the animal host such as digestion of cellulose and protection from invading pathogens. Read more
 Supervisor: Dr V Singh
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: Characterisation of human induced pluripotent stem cell derived kidney organoid system for use in drug discovery

Only 5% of all drugs tested in animal models are approved for human applications. Most of these failures are due to unexpected toxicity or lack of efficacy. The poor translation from small mammal studies to humans often causes this challenge. Read more
 Supervisor: Dr PD Davies
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: Human heart organoids for drug discovery in heart failure

Study of heart failure and heart attack is extremely difficult. Moreover, only 5% of all drugs tested in animal models are approved for human applications. Read more
 Supervisor: Dr PD Davies
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: Investigating Glycogen-Dependent Regulation of Microglia Inflammatory Responses

Microglia are the resident immune cells of the central nervous system, responsible for responding to infection and damage in a protective manner. Read more
 Supervisor: Dr A Lloyd
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: Exploring Bacillus biocontrol of Phytophthora raspberry root rot disease

Domestic crop production, increasingly reliant on reduced fertiliser and agrochemical inputs whilst also achieving high yields, is necessary to maintain a high level of food security in the UK. Read more
 Supervisors: Dr A Holmes, Prof N Stanley-Wall
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: Investigation of mitochondrial biology and neurodegeneration

Phosphorylation and ubiquitylation are reversible signalling events and there is significant interest in in their interplay in the regulation… Read more
 Supervisor: Prof M Muqit
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: Targeting ‘Undruggable’ Oncoproteins via Induced Proximity

Many well-established cancer drivers, such as K-Ras and β-catenin, have long been considered ‘undruggable’, as traditional drug development approaches have failed to effectively inhibit their activity. Read more
 Supervisors: Prof G Sapkota, Dr S Virdee
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: Functional mechanisms and inhibition of biomedically important calcium channels

Ion channels are key components in every cell, bridging cell and organellar membranes for the traversal of charged species. Calcium channels are of particular physiological importance because of the central role calcium plays in cell signalling and cell death. Read more
 Supervisors: Prof U Zachariae, Dr R Sknepnek
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: DNA Replication Coupled Mechanisms that control cell fate transitions

DNA replication is required for successful cell fate transitions across diverse physiological, experimental, and pathological contexts… Read more
 Supervisor: Dr C Alabert
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: Optimizing plant cell wall glycan extraction to support plant health and biotechnology research

Plant cell wall glycans are a major component of plant biomass, essential for plant physiology, development, and protection against environmental stress and disease. Read more
 Supervisor: Dr D Ndeh
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: Exploring temperature sensing pathways in barley

Mean global temperatures have risen by 1.5°C above pre-industrial levels and could climb by another 4°C by 2100. Read more
 Supervisor: Dr M Balcerowicz
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: Why are inhibitors of the protein kinase IRAK4 failing in Clinical Trials?

Hyperactivation of the Toll-Like Receptor (TLR) signalling pathway is a major cause of inflammatory and autoimmune diseases, suggesting that specific inhibitors of this pathway may have therapeutic potential for the treatment of diseases such as asthma, arthritis, colitis, lupus, psoriasis, and sepsis. Read more
 Supervisor: Prof Sir Philip Cohen
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc by Research: Conserved function of gut microbiome in mouse, fruit fly and Caenorhabditis elegans

Gut microbiome is the community of microbes living together in the gastrointestinal tract of an animal. They provide specific functions to the animal host such as digestion of cellulose and protection from invading pathogens. Read more
 Supervisors: Dr V Singh, Dr J Januschke
 Year round applications  PhD Research Project  Self-Funded PhD Students Only